Scr-IN-1
Product Specifications
Target
Apoptosis|||Src
Related Pathways
Tyrosine Kinase/Adaptors|||Apoptosis|||Angiogenesis
Bioactivity
Scr-IN-1 (Compound 4e) is a tyrosine kinase inhibitor demonstrating inhibitory activity against HCT-116 and MIA-PaCa-2 cells, with IC50 values of 0.16 ?M and 1.16 ?M, respectively. It shows selectivity towards HCT-116 cells and MIA-PaCa-2 cells, with a selectivity index (SI) greater than 625 and 86. Scr-IN-1 induces apoptosis in HCT-116 colon cancer cells without altering the proportion of necrotic cells and is a potential novel SRC kinase inhibitor for HCT-116 cells. This compound is suitable for cancer research.
Molecular Formula
C26H16ClF3N2O3
Molecular Weight
496.87
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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