What is the catalog number for EGFR/COX-2-IN-1?

The catalog number for EGFR/COX-2-IN-1 is T205462.

What sizes are available for EGFR/COX-2-IN-1?

EGFR/COX-2-IN-1 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does EGFR/COX-2-IN-1 come in?

EGFR/COX-2-IN-1 is available in 2 different pack sizes.

Is EGFR/COX-2-IN-1 in stock?

EGFR/COX-2-IN-1 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures EGFR/COX-2-IN-1?

EGFR/COX-2-IN-1 is manufactured by Molfinity.

What is the estimated delivery time for EGFR/COX-2-IN-1?

Estimated delivery time for EGFR/COX-2-IN-1 is approximately 10 business day(s), depending on your location.

EGFR/COX-2-IN-1

Product Specifications

Target

Apoptosis, COX, EGFR

Related Pathways

Immunology/Inflammation, Tyrosine Kinase/Adaptors, Angiogenesis, Neuroscience, Apoptosis, JAK/STAT signaling

Bioactivity

EGFR/COX-2-IN-1 is an EGFR/COX-2 inhibitor that effectively targets EGFRWT, EGFRT790M, COX-1, and COX-2 with IC50 values of 0.12, 0.076, 20.1, and 1.52 μM, respectively. It inhibits MCF-7, HT-29, and A-549 cells with IC50 values of 1.20, 5.14, and 14.81 μM, respectively. The compound induces apoptosis by upregulating Bax protein and downregulating Bcl-2 protein levels. Additionally, EGFR/COX-2-IN-1 significantly increases the proportion of cells in the G2/M phase in MCF-7 cells, demonstrating a broad-spectrum antitumor effect.