ROCK/HDAC-IN-2
Product Specifications
Target
ROCK, Apoptosis, HDAC
Related Pathways
Stem Cells, Chromatin/Epigenetic, DNA Damage/DNA Repair, Apoptosis, Cytoskeletal Signaling, Cell Cycle/Checkpoint
Bioactivity
ROCK/HDAC-IN-2 (Compound C-9) is a dual inhibitor of ROCK/HDAC, characterized by IC50 values of 0.185 μM for HDAC6, 0.8 μM for ROCK1, and 0.7 μM for ROCK2. It effectively induces apoptosis and mitochondrial membrane potential alterations in cancer cells and demonstrates notable antitumor activity, making it useful for research in pancreatic ductal adenocarcinoma (PDAC) and triple-negative breast cancer (TNBC) .
Molecular Formula
C22H32N4O4S
Molecular Weight
448.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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