What is the catalog number for VISTA-IN-4?

The catalog number for VISTA-IN-4 is T205442.

What sizes are available for VISTA-IN-4?

VISTA-IN-4 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does VISTA-IN-4 come in?

VISTA-IN-4 is available in 2 different pack sizes.

Is VISTA-IN-4 in stock?

VISTA-IN-4 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures VISTA-IN-4?

VISTA-IN-4 is manufactured by Molfinity.

What is the estimated delivery time for VISTA-IN-4?

Estimated delivery time for VISTA-IN-4 is approximately 10 business day(s), depending on your location.

VISTA-IN-4

Product Specifications

Target

Others

Related Pathways

Others

Bioactivity

VISTA-IN-4 (Compound B3) is an orally active inhibitor of the immune checkpoint protein VISTA, with a KD of 0.452 μM. It degrades VISTA in HepG2 cells with a degradation rate of 77% at a concentration of 5 μM. VISTA-IN-4 counteracts VISTA-mediated immune suppression, restoring T cell activity and promoting the release of cytokine IL-2. Additionally, it exhibits antitumor activity in CT26 xenograft mouse models and demonstrates favorable pharmacokinetic properties, with good oral serum exposure in SD rats, reflected by an AUC (0-t) of 412.9 mg·h/mL.