FLT3/VEGFR2-IN-1
Product Specifications
Target
FLT|||VEGFR|||STAT|||PERK|||HDAC
Related Pathways
Tyrosine Kinase/Adaptors|||Stem Cells|||Chromatin/Epigenetic|||JAK/STAT signaling|||DNA Damage/DNA Repair|||Apoptosis|||Angiogenesis
Bioactivity
FLT3/VEGFR2-IN-1 (Compound 26) is a potent inhibitor of FLT3, VEGFR2, and HDAC, exhibiting IC50 values of 14.5 nM, 3.9 nM, and 30.8 nM against FLT3, VEGFR2, and HDAC1, respectively. It effectively inhibits the phosphorylation of STAT3 and ERK1/2, as well as the proliferation of leukemia cells. FLT3/VEGFR2-IN-1 demonstrates antitumor activity and is applicable in research on acute myeloid leukemia.
Molecular Formula
C29H35N7O5
Molecular Weight
561.63
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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