K882
Product Specifications
Target
STAT, Ras, mTOR, JAK, Apoptosis, p38 MAPK, Akt, Survivin, Kras, IAP, Src
Related Pathways
Tyrosine Kinase/Adaptors, MAPK, Chromatin/Epigenetic, Angiogenesis, PI3K/Akt/mTOR signaling, Stem Cells, Apoptosis, GPCR/G Protein, Cytoskeletal Signaling, JAK/STAT signaling
Bioactivity
K882 (Compound 4e) is an Src inhibitor with a KD of 0.315 μM. It induces apoptosis and inhibits XIAP and Survivin. Additionally, K882 blocks the activation of the PI3K/Akt/mTOR, Jak1/Stat3, and Ras/MAPK signaling pathways. K882 exhibits antitumor activity against non-small cell lung cancer.
Molecular Formula
C18H16N2O2
Molecular Weight
292.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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