Antitumor agent-195
Product Specifications
Target
Reductase|||STAT
Related Pathways
JAK/STAT signaling|||Endocrinology/Hormones|||Stem Cells|||Metabolism
Bioactivity
Antitumor agent-195 (compound 16c) is a dual-targeting agent that simultaneously targets STAT3 and NQO1. At a concentration of 1 ?M, it significantly inhibits the phosphorylation of STAT3 at the Tyr705 site and effectively induces apoptosis in MDA-MB-231 and MDA-MB-468 breast cancer cells. As a substrate of NQO1, Antitumor agent-195 markedly increases ROS production, causing severe DNA damage in a dose-dependent manner. It also demonstrates strong antitumor properties in MDA-MB-231 xenograft models.
Molecular Formula
C22H22N2O4
Molecular Weight
378.42
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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