PPAR?/? agonist 3
Product Specifications
CAS Number
3050611-33-8
Target
PPAR
Related Pathways
DNA Damage/DNA Repair|||Metabolism
Bioactivity
PPAR?/? agonist 3 (Compound 8) is an orally active PPAR agonist capable of activating PPAR?, PPAR?, and PPAR?, with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. It exhibits anti-cholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA.
Smiles
O=C(O)C(OC=1C(=CC(=CC1C)CN2C(=O)N(C3=CC=C(C=C3)C(F)(F)F)CC2)C)(C)C
Molecular Formula
C23H25F3N2O4
Molecular Weight
450.451
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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