LYG-409
Product Specifications
CAS Number
3053857-55-6
Target
Molecular Glues
Related Pathways
PROTAC
Bioactivity
LYG-409 is an orally active GSPT1 degrader. It demonstrates exceptional in vivo anti-tumor activity against acute myeloid leukemia and prostate cancer, with tumor growth inhibition rates (TGI) of 94.34% and 104.49%, respectively. LYG-409 inhibits KG-1 cells by degrading GSPT1, with an IC50 of 9.50 nM and a DC50 of 7.87 nM in vitro.
Smiles
O=C(NCC1=CC=C2C(=O)N(CC2=C1)C3C(=O)NC(=O)CC3)C4=CC=5C=C(OC(F)(F)F)C=CC5OC4
Molecular Formula
C25H20F3N3O6
Molecular Weight
515.438
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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