Urotensin-II receptor antagonist-1
Product Specifications
CAS Number
1034708-07-0
Target
GPCR, Cytochromes P450, Opioid Receptor, Sodium Channel
Related Pathways
Endocrinology/Hormones, Metabolism, Neuroscience, Membrane transporter/Ion channel, GPCR/G Protein
Bioactivity
Urotensin-II receptor antagonist-1 (compound 1) is a human Urotensin II receptor antagonist with low oral bioavailability (F=0-3% in rats) and a Ki of 16 nM in HEK293 cells expressing human recombinant UT receptors. It inhibits cytochrome P450 enzymes (IC50=0.75 μM for CYP2D6; 1.4 μM for CYP3A4), suppresses κ opioid receptors (EC50=3.2 μM), and targets cardiac sodium channels (Ki=2.5 μM) .
Smiles
C([C@H]1[C@H](CCCN1C(CN(C)C2=CC(Cl)=C(Cl)C=C2)=O)C3=CC=CC=C3)N4CCCC4
Molecular Formula
C25H31Cl2N3O
Molecular Weight
460.439
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC471073-500 1x 500 µL
HLA-Aw32 & HLA-A25 (MHC I) (CATA-1), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC040806-100 1x 100 µL
TYRP1 (Tyrosinase Related Protein 1) (TA99), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC880676-500 1x 500 µL
MUC18 / Mucin 18 / CD146 (OJ79c), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC740270-500 1x 500 µL
Fibronectin (HFN7.1), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details