What is the catalog number for FGFRs-IN-1?

The catalog number for FGFRs-IN-1 is T205323.

What sizes are available for FGFRs-IN-1?

FGFRs-IN-1 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does FGFRs-IN-1 come in?

FGFRs-IN-1 is available in 2 different pack sizes.

Is FGFRs-IN-1 in stock?

FGFRs-IN-1 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures FGFRs-IN-1?

FGFRs-IN-1 is manufactured by Molfinity.

What is the estimated delivery time for FGFRs-IN-1?

Estimated delivery time for FGFRs-IN-1 is approximately 10 business day(s), depending on your location.

FGFRs-IN-1

Product Specifications

Target

VEGFR, FGFR, Cytochromes P450, FLT, Bcr-Abl

Related Pathways

Angiogenesis, Metabolism, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling

Bioactivity

FGFRs-IN-1 (Compound A16) is an orally active inhibitor targeting FGFR1/2/3/4, with IC50 values of 2.3, 7, 11, and 163 nM respectively. It also inhibits VEGFR1/2/3, Abl, and Flt3, with IC50 values of 61, 176, 112, 26, and 353 nM. The compound shows weak inhibition of CYP enzymes. FGFRs-IN-1 reduces the expression of α-SMA and collagen I, and it inhibits epithelial-mesenchymal transition (EMT) in A549 cells stimulated by TGF-β1. Additionally, FGFRs-IN-1 demonstrates anti-inflammatory activity in mouse models of lung fibrosis induced by Bleomycin and liver fibrosis induced by CCl4.