Tubulin polymerization-IN-77
Product Specifications
CAS Number
3023350-32-2
Target
Microtubule Associated
Related Pathways
Cytoskeletal Signaling
Bioactivity
Tubulin polymerization-IN-77 (Compound 15c) is a microtubule polymerization inhibitor that exhibits anti-glioblastoma activity by hindering microtubule polymerization. It demonstrates significant blood-brain barrier permeability, effectively induces G2/M phase arrest in GBM cells, and triggers apoptosis, while also markedly inhibiting tumor cell migration.
Smiles
O(C)C=1C=2[C@@](N(C(F)(F)F)CCC2C(Br)=C3C1OCO3)([C@@]4(C=5C(C(=O)O4)=C(OC)C(OC)=CC5)[H])[H]
Molecular Formula
C22H19BrF3NO7
Molecular Weight
546.288
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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