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JPHM-2-167

Product Specifications

CAS Number

1258877-17-6

Target

HIF/HIF Prolyl-Hydroxylase

Related Pathways

Chromatin/Epigenetic, Metabolism

Bioactivity

PHM-2-167 (Compound 11) is a selective inhibitor of the prolyl hydroxylase domain enzyme (PHD) . It inhibits PHD2 and PHD3 with IC50 values of 0.253 μM and 3.95 μM, respectively. PHM-2-167 is applicable for research in chronic kidney disease.

Smiles

O=C1N(C=2C=CC(=CC2)C=3C=CC=CC3)C(=O)C4(N1C5=NC=CC=N5)CCN(CC6=NC=CC=C6C)CC4

Molecular Formula

C30H28N6O2

Molecular Weight

504.582

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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