CQ1373
Product Specifications
Target
C-RET, Apoptosis
Related Pathways
Tyrosine Kinase/Adaptors, Apoptosis
Bioactivity
CQ1373 is a potent RET inhibitor that demonstrates cellular activity against BaF3 cells expressing CCDC6-RET, CCDC6-RET-G810C, and CCDC6-RET-G810R, with IC50 values of 13.0, 25.7, and 28.4 nM, respectively. It shows excellent selectivity for wild-type RET and solvent front mutants G810C/R, with IC50 values of 4.2, 7.1, and 32.4 nM. CQ1373 inhibits RET phosphorylation and downstream signaling through SHC. Additionally, it induces apoptosis (Apoptosis) and cell cycle arrest in BaF3 cells. CQ1373 possesses antitumor efficacy, making it a candidate for cancer research.
Smiles
COC1=CC(C2=C(/C=C/C3=CC(Cl)=C(NC(NC4=NOC(C(C)(C(F)(F)F)C)=C4)=O)C=C3)NN=C2)=CN=C1
Molecular Formula
C25H22ClF3N6O3
Molecular Weight
546.93
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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