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TCF4/?-catenin-IN-1

Product Specifications

Target

Wnt/beta-catenin|||Cytochromes P450|||Apoptosis|||Bcl-2 Family|||Caspase|||MDM-2/p53

Related Pathways

Apoptosis|||Proteases/Proteasome|||Cytoskeletal Signaling|||Metabolism|||Stem Cells

Bioactivity

TCF4/?-catenin-IN-1 (Compound 8b) is an inhibitor of TCF4/?-catenin that induces apoptosis. This compound enhances the expression of p53, caspase-3, caspase-8, caspase-9, and Bax proteins, while reducing Bcl-2 protein levels. TCF4/?-catenin-IN-1 also inhibits CYP3A4, CYP1A2, and CYP2C19, demonstrating significant cytotoxic activity in cancer cells.

Molecular Formula

C23H15N7O3

Molecular Weight

437.41

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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