TCF4/?-catenin-IN-1
Product Specifications
Target
Wnt/beta-catenin|||Cytochromes P450|||Apoptosis|||Bcl-2 Family|||Caspase|||MDM-2/p53
Related Pathways
Apoptosis|||Proteases/Proteasome|||Cytoskeletal Signaling|||Metabolism|||Stem Cells
Bioactivity
TCF4/?-catenin-IN-1 (Compound 8b) is an inhibitor of TCF4/?-catenin that induces apoptosis. This compound enhances the expression of p53, caspase-3, caspase-8, caspase-9, and Bax proteins, while reducing Bcl-2 protein levels. TCF4/?-catenin-IN-1 also inhibits CYP3A4, CYP1A2, and CYP2C19, demonstrating significant cytotoxic activity in cancer cells.
Molecular Formula
C23H15N7O3
Molecular Weight
437.41
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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