AXL/Angiokinase-IN-1
Product Specifications
Target
FGFR, Apoptosis, VEGFR, PDGFR
Related Pathways
Apoptosis, Angiogenesis, Tyrosine Kinase/Adaptors
Bioactivity
AXL/Angiokinase-IN-1 (compound 11b) is an inhibitor of AXL/triple angiokinase, with an IC50 of 3.75 nM for AXL expression. This compound suppresses epithelial-mesenchymal transition (EMT) in Bxpc-3 cells and prevents metastasis in lung cancer cells. Additionally, AXL/Angiokinase-IN-1 impairs the functions of vascular and fibroblast cells and induces apoptosis in both cancer and fibroblast cells. It is characterized by low toxicity and favorable metabolic stability.
Molecular Formula
C31H34ClN5O2
Molecular Weight
544.09
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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