Insecticidal agent 19
Product Specifications
Target
DHFR|||Parasite
Related Pathways
DNA Damage/DNA Repair|||Metabolism|||Microbiology/Virology|||Cell Cycle/Checkpoint
Bioactivity
Insecticidal agent 19 (Compound 7b) exhibits antimalarial activity by inhibiting dihydrofolate reductase-thymidylate synthase (DHFR-TS) and pteridine reductase 1 (PTR1) through the folate metabolic pathway. This compound also inhibits the promastigote and amastigote forms of Leishmania major, with IC50 values of 1.43 ?M and 3.78 ?M, respectively.
Molecular Formula
C26H15ClN4O6
Molecular Weight
514.87
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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