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EP-3945

Product Specifications

CAS Number

3057176-00-5

Target

MRGPR

Related Pathways

GPCR/G Protein

Bioactivity

EP-3945 is an agonist of Mas-related G protein-coupled receptors (MRGPR), exhibiting greater potency than the small molecule agonist ?-Alanine targeting MRGPRD. MRGPRs play a crucial role in inflammatory itch and pain perception. These receptors interact with Gq (MRGPRX2, MRGPRX4, and MRGPRX1 are coupled with Gq; MRGPRX2 and MRGPRD couple with Gi), with EP-3945 having an EC50 value of 211.6 nM for Gq.

Smiles

O=C1N=C(NC=2C=CC=CC12)NC3CCN(C(=O)C4(C5=CC=C(OC)C=C5)CC4)CC3

Molecular Formula

C24H26N4O3

Molecular Weight

418.488

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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