EP-3945
Product Specifications
CAS Number
3057176-00-5
Target
MRGPR
Related Pathways
GPCR/G Protein
Bioactivity
EP-3945 is an agonist of Mas-related G protein-coupled receptors (MRGPR), exhibiting greater potency than the small molecule agonist ?-Alanine targeting MRGPRD. MRGPRs play a crucial role in inflammatory itch and pain perception. These receptors interact with Gq (MRGPRX2, MRGPRX4, and MRGPRX1 are coupled with Gq; MRGPRX2 and MRGPRD couple with Gi), with EP-3945 having an EC50 value of 211.6 nM for Gq.
Smiles
O=C1N=C(NC=2C=CC=CC12)NC3CCN(C(=O)C4(C5=CC=C(OC)C=C5)CC4)CC3
Molecular Formula
C24H26N4O3
Molecular Weight
418.488
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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