HDAC3/BRD4-IN-1
Product Specifications
Target
Epigenetic Reader Domain|||HDAC
Related Pathways
DNA Damage/DNA Repair|||Chromatin/Epigenetic
Bioactivity
HDAC3/BRD4-IN-1 (compound 26n) is an inhibitor of HDAC3/BRD4, exhibiting an IC50 of 8 nM for HDAC3, while its IC50 values for HDAC1 and HDAC2 are 220 nM and 120 nM, respectively. It displays anti-tumor and anti-proliferative effects by upregulating Ac-H3 and downregulating c-Myc. The half-life of HDAC3/BRD4-IN-1 in human liver microsomes is 29.36 minutes.
Molecular Formula
C31H35N5O4
Molecular Weight
541.64
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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