Ontunisertib
Product Specifications
CAS Number
2647949-48-0
Target
TGF-beta/Smad
Related Pathways
Stem Cells
Bioactivity
Ontunisertib (Example 26) is a TGFβ receptor I/ALK5 (TGFβRI/ALK5) inhibitor with an IC50 value range of 100-500 nM for TGFβRI and an IC50 value of ≤100 nM for ALK5. This compound is applicable for research in gastrointestinal diseases, fibrosis-related conditions of the skin and eyes, and cancer.
Smiles
O=C(NCC=1C(F)=CC=CC1F)CN2N=C(C=3N=C(C=CC3)C)C(=C2)C=4C=CN=C5C=CC=CC54
Molecular Formula
C27H21F2N5O
Molecular Weight
469.485
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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