AZ3246
Product Specifications
CAS Number
2893978-54-4
Target
MAPK, Interleukin
Related Pathways
MAPK, Immunology/Inflammation
Bioactivity
AZ3246 is an orally active, selective inhibitor of HPK1 with an IC50 of less than 3 nM. It induces IL-2 secretion in T cells with an EC50 of 90 nM. AZ3246 also functions as a low-volume, low-clearance antitumor compound.
Smiles
O=C(N)C1=NC(=C(N=C1NC2=CN(N=C2C)CC(F)(F)F)C3CC3)C4=CN=CC5=C4N=CN5C
Molecular Formula
C21H20F3N9O
Molecular Weight
471.438
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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