TRPV1-IN-3
Product Specifications
Target
TRP/TRPV Channel
Related Pathways
Membrane transporter/Ion channel
Bioactivity
TRPV1-IN-3 (compound 14) is a TRPV1 inhibitor utilized in idiopathic pulmonary fibrosis research. It demonstrates antifibrotic activity in vitro (IC50 = 0.51 ?M) by inhibiting the TGF-?/Smads and MAPK pathways, thereby affecting the expression of fibrosis markers collagen I and ?-SMA. In vivo, TRPV1-IN-3 significantly reduces collagen deposition in lung tissue, improves alveolar structure, and increases survival rates in mice with Bleomycin-induced pulmonary fibrosis.
Smiles
C(=C/C(CCCCC1=CC=CC=C1)=O)\C2=CC(O)=C(O)C=C2
Molecular Formula
C19H20O3
Molecular Weight
296.36
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/315447168603259021/T205201
CAS Number
87657-67-8
Available Sizes
Curated Selection
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