DXR-IN-4

DXR-IN-4 (Compound 12a) is an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) . It effectively inhibits DXR in Plasmodium falciparum, Escherichia coli, and Mycobacterium tuberculosis, with IC50 values for PfDXR, EcDXR, and MtDXR at 18, 4.9, and 89 nM, respectively. Additionally, DXR-IN-4 demonstrates antimalarial activity against Plasmodium falciparum strains 3D7 and Dd2, with IC50 values of 11 μM and 12 μM.