SHP2-IN-35
Product Specifications
Target
Autophagy, Phosphatase, Akt, PI3K
Related Pathways
PI3K/Akt/mTOR signaling, Metabolism, Cytoskeletal Signaling, Autophagy
Bioactivity
SHP2-IN-35 (Compound 3f) functions as an inhibitor of SHP2. It exhibits antiproliferative activity in cancer cell lines RKO, SW480, and CT26, with IC50 values of 5.72 μM, 3.71 μM, and 1.42 μM, respectively. SHP2-IN-35 inhibits the PI3K-Akt signaling pathway, regulates the expression of cell cycle-related genes, and induces mitochondrial autophagy (autophagy) . Within the tumor microenvironment (TME), SHP2-IN-35 suppresses the expression of certain cytokines and chemokines, thereby modulating tumor progression.
Molecular Formula
C34H32FeO6
Molecular Weight
592.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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