PD-L1/HDAC-IN-1
Product Specifications
CAS Number
2923313-69-1
Target
PD-1/PD-L1, HDAC
Related Pathways
Apoptosis, Cell Cycle/Checkpoint, Chromatin/Epigenetic, Immunology/Inflammation, DNA Damage/DNA Repair
Bioactivity
PD-L1/HDAC-IN-1 (Compound 14) is an inhibitor of PD-L1 and HDAC, effectively blocking PD-1/PD-L1 interaction as well as HDAC2 and HDAC3 with IC50 values of 88.10, 27.98, and 14.47 nM, respectively. It exhibits mild cytotoxicity in MCF-7 cells (IC50=19.34 μM) and enhances the expression of PD-L1 and CXCL10, promoting antitumor immune responses by recruiting T cell infiltration into the tumor microenvironment (TME) .
Smiles
C(C1=C(OCC2=CC(C#N)=CC=C2)C=C(OCC3=C(C)C(=CC=C3)C4=CC(OCCCCCCC(NO)=O)=CC=C4)C(Cl)=C1)N5[C@@H](C(O)=O)CCCC5
Molecular Formula
C42H46ClN3O7
Molecular Weight
740.284
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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