Enpp-1-IN-25
Product Specifications
CAS Number
3067908-20-4
Target
PD-1/PD-L1, STING, PDE
Related Pathways
Metabolism, Cell Cycle/Checkpoint, Immunology/Inflammation, Apoptosis
Bioactivity
Enpp-1-IN-25 (Compound 30) is an ENPP1 inhibitor with an IC50 of 8.05 nM and exhibits low oral bioavailability. By inhibiting cGAMP degradation, it effectively activates the intracellular STING pathway. Enpp-1-IN-25 can enhance immune cell infiltration and type I interferon response in the tumor microenvironment, thereby increasing the antitumor efficacy of anti-PD-L1 antibodies. It is applicable for research in cancer immunotherapy.
Smiles
O=S(=O)(N)NCC1(O)CCN(C=2N=CN=C3C(OC)=CC=CC32)CC1
Molecular Formula
C15H21N5O4S
Molecular Weight
367.423
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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