SMD-1087

SMD-1087 is a selective PROTAC targeting SMARCA2 with a DC50 of 8 nM and a maximum degradation (Dmax) of 89%, while its DC50 for SMARCA4 exceeds 1 μM. The compound is composed of an E3 ligase ligand, (S, R, S) -AHPC-Me [blue part], a target protein ligand SMI-1074 [red part], and a PROTAC linker, (1r,4r) -tert-Butyl 4- (bromomethyl) cyclohexanecarboxylate [black part]. Notably, its target protein ligand plus linker section corresponds to the SMARCA2 Ligand-Linker Conjugate-1.

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