PBA-1105 TFA
Product Specifications
Target
AUTACs|||Autophagy
Related Pathways
PROTAC|||Autophagy
Bioactivity
PBA-1105 TFA is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. This compound selectively binds to the exposed hydrophobic regions of misfolded proteins, promoting their degradation through the autophagy (autophagy) pathway. Additionally, PBA-1105 TFA enhances the autophagic flux of Ub-bound aggregates.
Smiles
C1=CC=C(C=C1)CCCC(=O)NCCOCCOCCOCCNCC2=CC(=C(C=C2)OCC3=CC=CC=C3)OCC4=CC=CC=C4.C(=O)(C(F)(F)F)O
Molecular Formula
C41H49F3N2O8
Molecular Weight
754.832
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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