PD-L1/VISTA-IN-1
Product Specifications
CAS Number
2978623-09-3
Target
PD-1/PD-L1
Related Pathways
Cell Cycle/Checkpoint|||Apoptosis|||Immunology/Inflammation
Bioactivity
PD-L1/VISTA-IN-1 (Compound P17) is an orally active dual inhibitor targeting PD-L1 and VISTA. It effectively hinders the PD-1/PD-L1 interaction (IC50: 0.1492 ?M) and the VISTA pathway (KD: 0.2723 ?M), leading to the reactivation of T cells. Additionally, PD-L1/VISTA-IN-1 exhibits antitumor activity.
Smiles
CC1=C(C=CC=C1NC=2N=C(CN[C@H](C(O)=O)CO)C=C(OC)N2)C3=CC=CC=C3
Molecular Formula
C22H24N4O4
Molecular Weight
408.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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