SLW131
Product Specifications
CAS Number
681511-84-2
Target
CXCR
Related Pathways
Immunology/Inflammation, GPCR/G Protein, Autophagy
Bioactivity
SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.
Smiles
N([C@H]([C@@](C)(C)C)C=1OC(C)=CC1)C=2C(NC3=C(O)C(C(N(C)C)=O)=CC=C3)=NS(=O)(=O)N2
Molecular Formula
C21H27N5O5S
Molecular Weight
461.535
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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