PROTAC BTK Degrader-13

PROTAC BTK Degrader-13 (Compound 25) is a targeted BTK PROTAC degrader with a DC50 of 0.27 ?M. It inhibits BTK activity with an IC50 of 0.44 ?M and suppresses IL-2-induced T cell kinase (ITK) with an IC50 of 2.16 ?M. This compound also inhibits the p38 MAPK signaling pathway, thereby blocking the activation of the BCR (B cell receptor) signaling pathway. [Pink: ligand for target protein BTK ligand 15; Black: linker; Blue: ligand for E3 ligase cereblon]