What is the catalog number for JAK-IN-40?

The catalog number for JAK-IN-40 is T205062.

What sizes are available for JAK-IN-40?

JAK-IN-40 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does JAK-IN-40 come in?

JAK-IN-40 is available in 2 different pack sizes.

Is JAK-IN-40 in stock?

JAK-IN-40 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures JAK-IN-40?

JAK-IN-40 is manufactured by Molfinity.

What is the estimated delivery time for JAK-IN-40?

Estimated delivery time for JAK-IN-40 is approximately 10 business day(s), depending on your location.

JAK-IN-40

Product Specifications

Target

Apoptosis, STAT, JAK

Related Pathways

Stem Cells, Apoptosis, Chromatin/Epigenetic, JAK/STAT signaling, Angiogenesis, Tyrosine Kinase/Adaptors

Bioactivity

JAK-IN-40 (Compound 46) is an inhibitor of JAK, effectively targeting JAK1, JAK2, and JAK3 with IC50 values of 0.022, 0.759, and 1.601 μM, respectively. It reduces the phosphorylation of STAT3 and inhibits the proliferation of cancer cells Ba/F3 and JAK1-TEL Ba/F3 with GI50 values of 0.614 μM and 0.193 μM. JAK-IN-40 arrests cell cycle progression at the G2/M phase in H1975 and H2087 cells, leading to apoptosis. Additionally, JAK-IN-40 exhibits a synergistic anti-tumor effect when used in combination with Osimertinib.