JAK-IN-40
Product Specifications
Target
Apoptosis|||STAT|||JAK
Related Pathways
Stem Cells|||Apoptosis|||Chromatin/Epigenetic|||JAK/STAT signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors
Bioactivity
JAK-IN-40 (Compound 46) is an inhibitor of JAK, effectively targeting JAK1, JAK2, and JAK3 with IC50 values of 0.022, 0.759, and 1.601 ?M, respectively. It reduces the phosphorylation of STAT3 and inhibits the proliferation of cancer cells Ba/F3 and JAK1-TEL Ba/F3 with GI50 values of 0.614 ?M and 0.193 ?M. JAK-IN-40 arrests cell cycle progression at the G2/M phase in H1975 and H2087 cells, leading to apoptosis. Additionally, JAK-IN-40 exhibits a synergistic anti-tumor effect when used in combination with Osimertinib.
Molecular Formula
C26H32N8O3S
Molecular Weight
536.65
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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