Antitumor agent-196
Product Specifications
CAS Number
2705841-17-2
Target
Caspase|||Apoptosis|||Ferroptosis
Related Pathways
Proteases/Proteasome|||Apoptosis
Bioactivity
Antitumor agent-196 (Compound 6a (?, ?, ?) ) is an artemisinin-based oligomer with anticancer properties, exhibiting an IC50 of 90 nM against MCF-7 breast cancer cells. This compound induces apoptosis by modulating the Bax-caspase 3 signaling pathway and triggers ferroptosis by regulating key signaling molecules (including GPX4) . Antitumor agent-196 shows potential for cancer research applications.
Smiles
C[C@@H]1[C@]2([C@]34[C@@](O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])(O[C@@H]1OCCN(CCO[C@H]5O[C@]6([C@]78[C@]([C@H]5C)(CC[C@@H](C)[C@@]7(CC[C@](C)(O6)OO8)[H])[H])[H])CCO[C@H]9O[C@]%10([C@]%11%12[C@]([C@H]9C)(CC[C@@H](C)[C@@]%11(CC[C@](C)(O%10)OO%12)[H])[H])[H])[H])[H]
Molecular Formula
C51H81NO15
Molecular Weight
948.187
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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