DP-15
Product Specifications
CAS Number
3033837-71-4
Target
Apoptosis, PROTACs, Epigenetic Reader Domain
Related Pathways
Apoptosis, PROTAC, Chromatin/Epigenetic
Bioactivity
DP-15 acts as a degrader of GSPT1 and BRD4, with DC50 values of 5.25 nM and 0.48 nM, respectively. This compound exhibits antiproliferative activity in AML and NHL cells, showing IC50 values in the nanomolar range, induces G1 phase cell cycle arrest, and triggers apoptosis in MOLM13 cells. Additionally, DP-15 demonstrates anti-leukemic properties in the MOLM-13 xenograft mouse model. [Pink: ligand for target protein JQ-1 carboxylic acid; Black: linker; Blue: ligand for E3 ligaseCereblonThalidomide-5-OH]
Smiles
CC=1C2=C(N3C([C@H](CC(=O)N4CCN(CC5CCN(CC5)C=6C=C7C(=CC6)C(=O)N(C7=O)C8C(=O)NC(=O)CC8)CC4)N=C2C9=CC=C(Cl)C=C9)=NN=C3C)SC1C
Molecular Formula
C42H44ClN9O5S
Molecular Weight
822.374
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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