Pyrimidinone 8
Product Specifications
CAS Number
65004-42-4
Target
Ferroportin
Related Pathways
Membrane transporter/Ion channel
Bioactivity
Pyrimidinone 8 is a reversible, linear non-competitive inhibitor of divalent metal transporter 1 (DMT1) with a Ki of 20 ?M (hDMT1) . It does not affect the surface expression of hDMT1 and is not influenced by extracellular pH. Pyrimidinone 8 inhibits hDMT1-mediated iron uptake, with an IC50 of 13.8 ?M.
Smiles
O=C1N=C(NC(=C1)C)N2N=C(C=C2C)C
Molecular Formula
C10H12N4O
Molecular Weight
204.229
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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