TLR7 agonist 29
Product Specifications
Target
IFNAR, TLR, PD-1/PD-L1, ADC Cytotoxin
Related Pathways
Immunology/Inflammation, Apoptosis, Antibody-drug Conjugate/ADC Related, Cell Cycle/Checkpoint
Bioactivity
TLR7 agonist 29 (Compound 1) is an activator of TLR7, displaying an EC50 of 5.2 nM for human TLR7 and 48.2 nM for mouse TLR7. It can activate bone marrow-derived macrophages (BMDM) and stimulate myeloid cells within the tumor microenvironment, enhancing the expression of PD-L1, CD86, and IFN-α. Additionally, TLR7 agonist 29 can serve as a payload for synthesizing ADCs.
Molecular Formula
C20H27N7O2
Molecular Weight
397.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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