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ONO-2920632

Product Specifications

CAS Number

2230296-66-7

Target

Potassium Channel

Related Pathways

Membrane transporter/Ion channel

Bioactivity

ONO-2920632 is an orally active and CNS-penetrant TREK channel activator with EC50 values of 0.3 μM for TREK-1 and 2.8 μM for TREK-2. It demonstrates selectivity for other K2P channels, showing over 91-fold selectivity against TASK1, TASK2, TASK3, TRAAK, TWIK2, and 31-fold selectivity against TRESK. ONO-2920632 exhibits analgesic effects and is used in the study of pain, migraine, and neurological disorders.

Smiles

O=C(NCC1=CC=C(OC(F)(F)F)C=C1F)C=2C=CC3=NC=NN3C2

Molecular Formula

C15H10F4N4O2

Molecular Weight

354.259

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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