ONO-2920632
Product Specifications
CAS Number
2230296-66-7
Target
Potassium Channel
Related Pathways
Membrane transporter/Ion channel
Bioactivity
ONO-2920632 is an orally active and CNS-penetrant TREK channel activator with EC50 values of 0.3?µM for TREK-1 and 2.8?µM for TREK-2. It demonstrates selectivity for other K2P channels, showing over 91-fold selectivity against TASK1, TASK2, TASK3, TRAAK, TWIK2, and 31-fold selectivity against TRESK. ONO-2920632 exhibits analgesic effects and is used in the study of pain, migraine, and neurological disorders.
Smiles
O=C(NCC1=CC=C(OC(F)(F)F)C=C1F)C=2C=CC3=NC=NN3C2
Molecular Formula
C15H10F4N4O2
Molecular Weight
354.259
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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