DS79932728
Product Specifications
CAS Number
2757191-62-9
Target
Glucagon Receptor, Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic, GPCR/G Protein
Bioactivity
DS79932728 is an orally active inhibitor of G9a and GLP, with IC50 values of 12.6 nM and 75.7 nM, respectively. It induces the production of γ-globin, thereby increasing fetal hemoglobin (HbF) levels. In cynomolgus monkey models, DS79932728 enhances the proportion of F-reticulocytes (F-rets) and shows good oral absorption characteristics.
Smiles
N=1C2=CC(=C(OC)C=C2C3(C1N)CCC3)C4=CCN(C)CCC4
Molecular Formula
C19H25N3O
Molecular Weight
311.421
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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