DDO-2728
Product Specifications
CAS Number
3029515-97-4
Target
Others
Related Pathways
Others
Bioactivity
DDO-2728 is a selective pyrazolopyrimidine ALKBH5 inhibitor with an IC50 of 2.97 μM. It enhances the level of N6-methyladenosine (m6A) modification in acute myeloid leukemia (AML) cells and exhibits antiproliferative activity in these cells. Additionally, it demonstrates antitumor efficacy in MV4-11 xenograft models.
Smiles
O=C(OCC1=CC=C(C=C1)C(F)(F)F)C=2C=CC(=CC2)C3=NN4C=C(C=NC4=C3)C(=O)C=5C(O)=CC=C(C5O)N(=O)=O
Molecular Formula
C28H17F3N4O7
Molecular Weight
578.452
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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