DDN
Product Specifications
CAS Number
118006-14-7
Target
IGF-1R, ERK, Akt
Related Pathways
Tyrosine Kinase/Adaptors, MAPK, PI3K/Akt/mTOR signaling, Cytoskeletal Signaling
Bioactivity
DDN is a selective Insulin Receptor activator and insulin sensitizer that mimics insulin activity with oral efficacy. It can directly bind to the receptor kinase domain, inducing Akt and ERK phosphorylation, and enhances insulin-stimulated glucose uptake. DDN significantly reduces blood glucose levels in wild-type and diabetic ob/ob and db/db mice.
Smiles
O=C1C(Cl)=C(Cl)C(=O)C=2C(OC(=O)C)=CC=C(OC(=O)C)C12
Molecular Formula
C14H8Cl2O6
Molecular Weight
343.116
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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