BNN27
Product Specifications
CAS Number
1195795-81-3
Target
Apoptosis, Trk receptor
Related Pathways
Tyrosine Kinase/Adaptors, Apoptosis
Bioactivity
BNN27 is an agonist of the TrkA receptor (TrkAreceptor) and the p75NTR receptor (p75NTR receptor), exhibiting neurotrophic and anti-apoptotic properties. It enhances levels of glutamate, GABA, and glutamine in the hippocampus and prefrontal cortex of rats, improving glutamate turnover. In a mouse model of amyotrophic lateral sclerosis (ALS), BNN27 demonstrates neuroprotective effects, shows anti-inflammatory properties in an experimental autoimmune encephalomyelitis (EAE) model, and exhibits retinal protection in a rat diabetes model. BNN27 also possesses blood-brain barrier permeability.
Smiles
C[C@@]12[C@@]3([C@@H](CO)O3)CC[C@]1([C@]4([C@](CC2)([C@]5(C)C(=CC4)C[C@@H](O)CC5)[H])[H])[H]
Molecular Formula
C21H32O3
Molecular Weight
332.477
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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