HTR2A antagonist 1
Product Specifications
Target
Apoptosis|||5-HT Receptor
Related Pathways
GPCR/G Protein|||Apoptosis|||Neuroscience
Bioactivity
HTR2A antagonist 1 (Compound 15f) is an HTR2A antagonist with an IC50 of 42.79 nM. It induces sub-G1 cell cycle arrest and apoptosis in colorectal cancer cells by activating the p53/p21/caspase 3 signaling pathway. HTR2A antagonist 1 exhibits good liver microsomal stability and is useful for colorectal cancer research.
Smiles
C1CNCCC1N(CC2=CC=C(C=C2)F)C(=O)NCC3=CC=C(C=C3)OCC(CN4CCC(CC4)C5=NOC6=C5C=CC(=C6)F)O.Cl.Cl
Molecular Formula
C35H43Cl2F2N5O4
Molecular Weight
706.65
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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