EGFR-IN-141
Product Specifications
CAS Number
3054263-27-0
Target
Apoptosis|||EGFR
Related Pathways
JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Angiogenesis|||Apoptosis
Bioactivity
EGFR-IN-141 (Compound 8I) functions as an EGFR inhibitor with an IC50 of 2.67 nM. It exhibits cytotoxicity in A549 cancer cells with an IC50 of 13.75 ?M. EGFR-IN-141 induces apoptosis and mitochondrial membrane depolarization and shows potential antitumor activity.
Smiles
O=C1C=2C=CC=CC2N=CN1CC3=NN=C(SCC(=O)NC4=NC=5C=CC(F)=CC5S4)N3N
Molecular Formula
C20H15FN8O2S2
Molecular Weight
482.514
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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