Dual Galectin-3/EGFR-IN-1
Product Specifications
Target
EGFR, Apoptosis, Galectin
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Immunology/Inflammation, JAK/STAT signaling, Apoptosis
Bioactivity
Dual Galectin-3/EGFR-IN-1 (Compound 29) is a dual inhibitor targeting Galectin-3 and EGFR, with dissociation constants (KD) of 52.29 μM and 3.31 μM, respectively. It inhibits TGF-β-induced hepatic stellate cell (HSC) activation, induces apoptosis in LX-2 cells, and shows antifibrotic activity in the liver.
Smiles
CC(=O)NC1C(C(C(OC1OCCN2C=C(N=N2)C3=CC(=CC=C3)NC4=NC=NC5=CC(=C(C=C54)OCCOC)OCCOC)CO)O)O
Molecular Formula
C32H41N7O10
Molecular Weight
683.709
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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