CQ627
Product Specifications
Target
Serine/threonin kinase, Molecular Glues, Apoptosis
Related Pathways
Metabolism, PROTAC, Apoptosis, Cell Cycle/Checkpoint
Bioactivity
CQ627 is a molecular glue that targets the degradation of RIOK2. It effectively recruits the E3 ubiquitin ligase RNF126, inducing the proteasomal degradation of RIOK2 via the ubiquitin-proteasome system (UPS) in MOLT4 leukemia cell lines, with a DC50 value of 410 nM. Additionally, CQ627 induces apoptosis in a dose-dependent manner in these cells, blocking the cell cycle at the G2/M phase, and exhibits antiproliferative activity across various cancer cell lines. It also demonstrates in vivo anticancer activity in MOLT4 xenograft mouse models.
Smiles
COC1=NC=C(C=C1)C2=CC3=C(C=C2)NC(=O)C4=C3N(N=N4)C5=CC(=C(C=C5)N6CCN(CC6)C(=O)/C=C/C(=O)C7=CC=C(C=C7)F)C(F)(F)F
Molecular Formula
C36H27F4N7O4
Molecular Weight
697.638
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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