NDM-1 inhibitor-8
Product Specifications
Target
Beta-lactamase, Antibacterial
Related Pathways
Microbiology/Virology
Bioactivity
NDM-1 inhibitor-8 (Compound 18b) is a covalent inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1), with an IC50 of 7.03 μM. It effectively inhibits resistant bacterial strains and demonstrates synergistic antibacterial effects when used in combination with Meropenem. In mouse models, NDM-1 inhibitor-8 exhibits anti-infective activity.
Smiles
C1C(=C(N2[C@H](S1)[C@@H](C2=O)NCC3=CC(=CC(=C3)Cl)Cl)C(=O)O)C[Se]C4=CC=CC=C4C(=O)NC5=CC=CC=C5
Molecular Formula
C28H23Cl2N3O4SSe
Molecular Weight
647.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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